Mirabilis multiflora is a species of flowering plant in the four o'clock family known by the common name Colorado four o'clock that is native to the southwestern United States from California to Colorado and Texas, as well as far northern Mexico, where it grows in mostly dry habitat types in a number of regions.
Among the Zuni people, the powdered root is mixed with flour, made into a bread, and used to decrease appetite. An infusion of the root is taken and rubbed on the abdomen of hungry adults and children. An infusion of the powdered root is taken by adults or children after overeating.
M. multiflora's reproduction is dependent on hawkmoths for pollination.